Psilomethoxin #

Psilomethoxin (Pm) offers soothing comfort similar to MDMA, but without MDMA’s stimulant-like effects.1

For more information, read my case report.


Credit: Christopher Scott

Contraindications #

Since psilomethoxin is similar to 5-MeO-DMT, it is prudent to regard contraindications for 5-MeO-DMT as contraindications for psilomethoxin until we have more data.

  • Allergy to Psilocybe mushrooms2
  • Epilepsy (a strong contraindication for 5-MeO-DMT)
  • 5-MeO-DMT interacts with CYP2D6 and monoamine oxidase (MAO) inhibitors.
    • CYP2D6 inhibitors such as Paroxetine, Bupropion, Quinidine, etc
    • MAO inhibitors such as beta carbolines, harmala alkaloids, moclobemide, etc
  • Serotonin reuptake inhibitors
  • Lithium
  • Pregnancy or breastfeeding

Sources for this information include:

Notes #

  1. Effects of Psilomethoxin from Experienced 5-MeO-DMT Practitioner ↩︎

  2. The Church of Sacred Synthesis distributes sacrament as dried Psilocybe mushroom powder. Although many mushrooms of the Psilocybe genus produce psilocybin and psilocin, the manufacturing process devised by the church ensures that psilomethoxin is produced with only trace amounts of psilocybin or psilocin. ↩︎