Psilomethoxin (Pm) offers soothing comfort similar to MDMA, but without MDMA’s stimulant-like effects.1
For more information, read my case report.
Credit: Christopher Scott
Since psilomethoxin is similar to 5-MeO-DMT, it is prudent to regard contraindications for 5-MeO-DMT as contraindications for psilomethoxin until we have more data.
- Allergy to Psilocybe mushrooms2
- Epilepsy (a strong contraindication for 5-MeO-DMT)
- 5-MeO-DMT interacts with CYP2D6 and monoamine oxidase (MAO) inhibitors.
- CYP2D6 inhibitors such as Paroxetine, Bupropion, Quinidine, etc
- MAO inhibitors such as beta carbolines, harmala alkaloids, moclobemide, etc
- Serotonin reuptake inhibitors
- Pregnancy or breastfeeding
Sources for this information include:
- F.I.V.E.’s Risks and Cautions
- Psilomethoxin: The History, Testing, Pharmacodynamics, and Pharmacokinetics
- Evidence and Data Regarding the Safety of Psilomethoxin Sacrament
Effects of Psilomethoxin from Experienced 5-MeO-DMT Practitioner ↩︎
The Church of Psilomethoxin distributes sacrament as dried Psilocybe mushroom powder. Although many mushrooms of the Psilocybe genus produce psilocybin and psilocin, the manufacturing process devised by the church insures that only psilomethoxin is produced without a trace of psilocybin or psilocin. ↩︎